Copper Catalyst-Supported Modified Magnetic Chitosan for the Synthesis of Novel 2-Arylthio-2,3-dihydroquinazolin-4(1H)-one Derivatives via Chan–Lam Coupling
نویسندگان
چکیده
In this paper, magnetic chitosan is used as a support for the immobilization of copper catalyst (Cu@MChit). The fabricated successfully synthesized and characterized by several techniques. activity Cu@MChit evaluated in synthesis novel derivatives 3-alkyl-2-arylthio-2,3-dihydroquinazolin-4(1H)-ones. products are three simple steps via Chan–Lam coupling reaction. synthetic route based on reaction isatoic anhydride an amine, followed with carbon disulfide. Cu@MChit-catalyzed obtained intermediate phenylboronic acid leads to desired products. scope confirmed using various amine high isolated yields.
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ژورنال
عنوان ژورنال: Inorganics (Basel)
سال: 2022
ISSN: ['2304-6740']
DOI: https://doi.org/10.3390/inorganics10120231